Kay Neil E, Pittner Brian T
Division of Hematology, Department of Medicine, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, USA.
Leuk Lymphoma. 2003 Jun;44(6):897-903. doi: 10.1080/1042819031000068007.
This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.
本综述阐述了白细胞介素-4（IL-4）在正常和白血病性慢性淋巴细胞白血病（CLL）B细胞中的作用。IL-4是一种特性明确的细胞因子，已知由正常T细胞产生，并对正常B细胞的分化和增殖有影响。现在已知这种细胞因子及其受体存在于CLL B细胞上。信号转导事件、凋亡蛋白的改变以及凋亡抗性的变化有力地支持了CLL B细胞的自分泌途径。基于对IL-4途径的认识不断增加，现在B-CLL有了独特的治疗机会。
