Hoshi J, Nishida H, Yasui M, Ohishi M, Takahashi M
Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
Acta Paediatr Jpn. 1992 Dec;34(6):674-7. doi: 10.1111/j.1442-200x.1992.tb01030.x.
It is suitable to examine the utilization of carbohydrates and fats using stable isotope-labelled substrates in neonates because of their non-radioactivity. Administering medium-chain triglycerides (MCT) and oligosaccharides is of use in enteral nutrition for a patient with a limited water intake such as a neonate. In this study, the oxidation of MCT and maltose administered orally as an energy supplement in neonates has been examined using a stable isotope-labelled breath test. Five normal term neonates and five growing preterm infants were given [13C]-trioctanoin orally and three growing preterm infants were given [13C]-glucose and [13C]-maltose orally. The [13C] enrichment in carbon dioxide was analyzed by isotope ratio mass spectrometry, and oxidation rates over 6 hr and 12 hr respectively, were calculated. The oxidation rates for [13C]-octanoin after 6 hr were 46.2 +/- 3.6% in preterm infants and 53.5 +/- 13.8% in normal neonates, respectively (no significant difference), and 58.4 +/- 9.4% and 52.8 +/- 6.0% for [13C]-glucose and [13C]-maltose, respectively (not significant). The results demonstrate that orally administered MCT and maltose are oxidized sufficiently in preterm infants.
由于其无放射性，使用稳定同位素标记的底物来检测新生儿碳水化合物和脂肪的利用率是合适的。对于水摄入量有限的患者（如新生儿），给予中链甘油三酯（MCT）和低聚糖用于肠内营养是有用的。在本研究中，已使用稳定同位素标记的呼气试验检测了口服给予新生儿作为能量补充剂的MCT和麦芽糖的氧化情况。对5名足月正常新生儿和5名生长中的早产儿口服给予[13C] - 三辛酸甘油酯，对3名生长中的早产儿口服给予[13C] - 葡萄糖和[13C] - 麦芽糖。通过同位素比率质谱法分析二氧化碳中的[13C]富集情况，并分别计算6小时和12小时的氧化率。早产儿6小时后[13C] - 辛酸甘油酯的氧化率分别为46.2±3.6%，正常新生儿为53.5±13.8%（无显著差异），[13C] - 葡萄糖和[13C] - 麦芽糖的氧化率分别为58.4±9.4%和52.8±6.0%（无显著差异）。结果表明，口服给予的MCT和麦芽糖在早产儿中能充分氧化。
