Sulkers E J, Lafeber H N, Sauer P J
Department of Paediatrics, Erasmus University, Rotterdam, The Netherlands.
Pediatr Res. 1989 Oct;26(4):294-7. doi: 10.1203/00006450-198910000-00003.
Medium-chain triglycerides, with a chain length of eight and 10 carbon atoms, form up to 50% of the total fat content in some preterm infant formulas. In 20 small preterm infants (birthwt: 1153 +/- 227 g; mean +/- SD) fed a special formula containing 40% MCT, a primed constant oral infusion study of 1-13C-potassium octanoate was conducted to quantify the oxidation of MCT. A plateau in 13C enrichment in breath CO2 was reached in all patients within 1-3 h. Simultaneously, substrate utilization was measured using a closed system indirect calorimeter. No significant difference was found between appropriate for gestational age (n = 8) and small for gestational age (n = 12) infants in the percentage of the administered tracer that was oxidized (44.9 +/- 9.1% versus 48.5 +/- 11.0%). In all patients, the recovery was calculated to be 47.1 +/- 10.2%, which is less than previously estimated and corresponds to a mean MCT oxidation of 1.26 +/- 0.27 g/kg/d. With indirect calorimetry, a total fat oxidation of 1.42 +/- 0.84 g/kg/d in appropriate for gestational age and 2.00 +/- 0.85 g/kg/d in small for gestational age infants was found, indicating that MCT accounted for around 85% of the total fat oxidation in appropriate for gestational age versus 65% in small for gestational age infants.
链长为8至10个碳原子的中链甘油三酯在某些早产儿配方奶粉中占总脂肪含量的比例高达50%。在20名小早产儿（出生体重：1153±227克；平均值±标准差）中，喂养一种含40%中链甘油三酯的特殊配方奶粉，进行了一项关于1-13C-辛酸钾的首剂量恒定口服输注研究，以量化中链甘油三酯的氧化情况。所有患者在1至3小时内呼气二氧化碳中的13C富集达到平稳状态。同时，使用封闭系统间接热量计测量底物利用率。适于胎龄儿（n = 8）和小于胎龄儿（n = 12）在氧化的给药示踪剂百分比方面未发现显著差异（分别为44.9±9.1%和48.5±11.0%）。在所有患者中，回收率计算为47.1±10.2%，低于先前估计，相当于中链甘油三酯的平均氧化量为1.26±0.27克/千克/天。通过间接热量测定法发现，适于胎龄儿的总脂肪氧化量为1.42±0.84克/千克/天，小于胎龄儿为2.00±0.85克/千克/天，这表明中链甘油三酯在适于胎龄儿的总脂肪氧化中约占85%，而在小于胎龄儿中占65%。
