Cunningham R, Dale B, Undy B, Gaunt N
Plymouth Public Health Laboratory, Derriford Hospital, Plymouth, UK.
J Hosp Infect. 2003 Jul;54(3):243-5. doi: 10.1016/s0195-6701(03)00088-4.
Clostridium difficile is the main infectious cause of colitis in hospital inpatients. The incidence is increasing, and it is associated with significant mortality, morbidity, and increased length of stay. The main risk factor is use of broad-spectrum antibiotics, and antibiotic restriction is the most effective control measure. We carried out a retrospective case-control study to investigate whether use of proton pump inhibitors (PPI) was an additional risk factor. PPI use within the preceding eight weeks was associated with an increased risk of C. difficile diarrhoea (odds ratio 2.5, 95% CI 1.5-4.2). Reduction of unnecessary PPI use may be an additional strategy to reduce the incidence of this infection.
艰难梭菌是医院住院患者结肠炎的主要感染病因。其发病率正在上升，且与显著的死亡率、发病率及住院时间延长相关。主要危险因素是使用广谱抗生素，而限制抗生素使用是最有效的控制措施。我们开展了一项回顾性病例对照研究，以调查使用质子泵抑制剂（PPI）是否为另一危险因素。在之前八周内使用PPI与艰难梭菌腹泻风险增加相关（比值比2.5，95%可信区间1.5 - 4.2）。减少不必要的PPI使用可能是降低这种感染发病率的另一策略。
