Fuchsjäger-Mayrl Gabriele, Malec Magdalena, Amoako-Mensah Tina, Kolodjaschna Julia, Schmetterer Leopold
Department of Clinical Pharmacology, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
Vision Res. 2003 Sep;43(20):2185-90. doi: 10.1016/s0042-6989(03)00332-8.
It has recently been reported that light/dark transitions lead to changes in choroidal blood flow. Several observations indicate that these changes in choroidal perfusion are triggered at least in part by neural mechanisms. In the present study we hypothesised that the choroidal blood flow response to changes in retinal illumination may be modified by either the muscarinic receptor antagonist atropine or by the beta-receptor antagonist propranolol. In 15 healthy subjects the response of choroidal perfusion was studied in a randomised placebo-controlled three way cross-over study using laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude. Before drug administration a transition from light to dark reduced both choroidal haemodynamic parameters by 8%-12%. Neither propranolol nor atropine altered basal choroidal blood flow or choroidal blood flow responses to light/dark transitions. Our data indicate that neither muscarinic nor beta-receptors are involved in the choroidal blood flow response to changes in retinal illumination. Further studies are required to elucidate which mechanisms contribute to this blood flow behaviour of the choroid.
最近有报道称，明暗转换会导致脉络膜血流发生变化。多项观察结果表明，脉络膜灌注的这些变化至少部分是由神经机制触发的。在本研究中，我们假设，毒蕈碱受体拮抗剂阿托品或β受体拮抗剂普萘洛尔可能会改变脉络膜血流对视网膜光照变化的反应。在15名健康受试者中，采用激光多普勒血流仪和眼底搏动幅度激光干涉测量法，在一项随机、安慰剂对照的三向交叉研究中研究了脉络膜灌注的反应。在给药前，从明到暗的转换使两个脉络膜血流动力学参数均降低了8%-12%。普萘洛尔和阿托品均未改变基础脉络膜血流或脉络膜血流对明暗转换的反应。我们的数据表明，毒蕈碱受体和β受体均不参与脉络膜血流对视网膜光照变化的反应。需要进一步研究以阐明哪些机制导致了脉络膜的这种血流行为。
