Berkowitz Bruce A, Bissig David, Roberts Robin
Dept. of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA; Dept. Of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.
Dept. of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
Prog Retin Eye Res. 2016 Mar;51:90-106. doi: 10.1016/j.preteyeres.2015.09.001. Epub 2015 Sep 4.
Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.
视杆细胞氧化应激是视网膜疾病（如糖尿病性视网膜病变（DR）和色素性视网膜炎（RP））的主要致病因素。由于目前的成像方法无法在体内分析测量针对视杆细胞特定区域氧化应激的治疗效果，因此针对这些疾病的个性化、非侵入性和靶向治疗仍然难以实现。在过去十年中，已经开发出了基于磁共振成像（MRI）的新方法来弥补这一技术差距。本综述总结了自2006年以来MRI的发展进展，这些进展能够比目前其他方法更早地评估疾病对视杆细胞特定区域功能的影响以及抗氧化治疗的效果。大多数视杆细胞特定区域功能的新检测方法基于内源性对比机制，这有望促进其转化应用于DR和RP患者以及其他基于氧化应激的视网膜疾病患者。
