Bruce J, Drury N, Poobalan A S, Jeffrey R R, Smith W C S, Chambers W A
Department of Public Health, University of Aberdeen, Polwarth Building, Medical School, Foresterhill, Aberdeen, AB25 2ZD, UK.
Pain. 2003 Jul;104(1-2):265-73. doi: 10.1016/s0304-3959(03)00017-4.
Chronic pain after surgery is recognised as an important post-operative complication; recent studies have shown up to 30% of patients reporting persistent pain following mastectomy and inguinal hernia repair. No large-scale studies have investigated the epidemiology of chronic pain at two operative sites following coronary artery bypass grafting (CABG). This paper reports the follow-up of a cohort of 1348 patients who underwent cardiac surgery between 1996 and 2000 at one cardiothoracic unit in northeast Scotland. Chronic pain was defined as pain in the location of surgery, different from that suffered pre-operatively, arising post-operatively and persisting beyond 3 months. The survey questionnaire consisted of the short-form-36 (SF-36), Rose angina questionnaire, McGill pain questionnaire and the University of California and San Francisco (UCSF) pain service questionnaire. Of the 1080 responders, 130 reported chronic chest pain, 100 chronic post-saphenectomy pain and 194 reported pain at both surgical sites. The cumulative prevalence of post-cardiac surgery pain was 39.3% (CI(95) 36.4-42.2%) and mean time of 28 months since surgery (SD 15.3 months). Patients who reported pain at both sites had lower quality of life scores across all eight health domains compared to patients with pain at one site only and those who were pain-free. Prevalence of chronic pain decreased with age, from 55% in those aged under 60 years to 34% in patients over 70 years. Patients with pre-operative angina and those who were overweight or obese (BMI>/=25) at the time of surgery were more likely to report chronic pain. Chronic pain following median sternotomy and saphenous vein harvesting is more common than hitherto reported and that patients undergoing CABG should be warned of this possibility.
术后慢性疼痛被认为是一种重要的术后并发症;最近的研究表明,高达30%的患者在乳房切除术后和腹股沟疝修补术后报告有持续性疼痛。尚无大规模研究调查冠状动脉旁路移植术(CABG)后两个手术部位慢性疼痛的流行病学情况。本文报告了1996年至2000年期间在苏格兰东北部一个心胸外科单位接受心脏手术的1348名患者队列的随访情况。慢性疼痛定义为手术部位的疼痛,与术前疼痛不同,术后出现且持续超过3个月。调查问卷包括简短健康调查问卷(SF - 36)、罗斯心绞痛问卷、麦吉尔疼痛问卷以及加利福尼亚大学旧金山分校(UCSF)疼痛服务问卷。在1080名回复者中,130人报告有慢性胸痛,100人报告有隐静脉切除术后慢性疼痛,194人报告两个手术部位都有疼痛。心脏手术后疼痛的累积患病率为39.3%(95%置信区间36.4 - 42.2%),自手术以来的平均时间为28个月(标准差15.3个月)。与仅在一个部位疼痛的患者和无疼痛的患者相比,报告两个部位都疼痛的患者在所有八个健康领域的生活质量得分更低。慢性疼痛的患病率随年龄下降,从60岁以下患者的55%降至70岁以上患者的34%。术前有心绞痛以及手术时超重或肥胖(BMI≥25)的患者更有可能报告慢性疼痛。正中胸骨切开术和大隐静脉采集术后的慢性疼痛比迄今报道的更为常见,接受CABG手术的患者应被告知这种可能性。