Schulze S, Niggemann B, Savaser A N, Wahn U
University Children's Hospital (KAVH), Berlin, Germany.
Allergy. 1992 Dec;47(6):644-9. doi: 10.1111/j.1398-9995.1992.tb02389.x.
In order to establish a noninvasive method of monitoring immediate hypersensitivity reactions in children, we studied the diurnal variation of urinary histamine and 1-methylhistamine excretion and the influence of food intake in a group of 14 healthy nonatopic children (aged 2-16 years). Histamine and 1-methylhistamine in spontaneous urine samples were determined by radioimmunoassay. Mean variation of 2-h intervals was much higher for urinary histamine than for 1-methylhistamine (45% of base-line level versus 24%). There was no circadian rhythm or influence of food intake. The short half-life of histamine released into blood circulation may be the main reason for the higher variation of histamine excretion. In children, urinary 1-methylhistamine is less influenced by diurnal variation and is therefore more suited to monitor immediate hypersensitivity reactions than urinary histamine itself.
为建立一种监测儿童速发型超敏反应的非侵入性方法，我们研究了14名健康非特应性儿童（2至16岁）尿中组胺和1-甲基组胺排泄的日变化以及食物摄入的影响。通过放射免疫分析法测定自发尿样中的组胺和1-甲基组胺。尿组胺2小时间隔的平均变化比1-甲基组胺高得多（分别为基线水平的45%和24%）。不存在昼夜节律或食物摄入的影响。释放到血液循环中的组胺半衰期较短可能是组胺排泄变化较大的主要原因。在儿童中，尿1-甲基组胺受日变化的影响较小，因此比尿组胺本身更适合监测速发型超敏反应。
