组氨酸血症患者的组胺代谢：尿中组胺、Nτ-甲基组胺、咪唑乙酸及其共轭物水平的测定

Histamine metabolism in patients with histidinemia: determination of urinary levels of histamine, N tau-methylhistamine, imidazole acetic acid, and its conjugate(s).

作者信息

Imamura I, Watanabe T, Hase Y, Sakamoto Y, Fukuda Y, Yamamoto H, Tsuruhara T, Wada H

出版信息

J Biochem. 1984 Dec;96(6):1925-9. doi: 10.1093/oxfordjournals.jbchem.a135027.

DOI:10.1093/oxfordjournals.jbchem.a135027

Abstract

Histamine metabolism in histidinemic patients was studied by measuring the urinary levels of histamine and its metabolites. The urinary excretions of histamine, N tau-methylhistamine, imidazole acetic acid, and its conjugate(s) were higher in patients with histidinemia than in controls, and these levels of excretion were correlated with the plasma histidine level. The urinary histamine levels of patients with eczema-like dermatitis were twice that of those without dermatitis. The urinary excretion of 3-methylhistidine showed a close correlation with the urinary histidine excretion. Thus, it was concluded that histamine metabolism is higher in histidinemic patients than in normal controls.

摘要

通过测量组胺及其代谢产物的尿水平，研究了组氨酸血症患者的组胺代谢。组氨酸血症患者尿中组胺、N-τ-甲基组胺、咪唑乙酸及其结合物的排泄量高于对照组，且这些排泄水平与血浆组氨酸水平相关。患有湿疹样皮炎的患者尿组胺水平是无皮炎患者的两倍。3-甲基组氨酸的尿排泄量与尿组氨酸排泄量密切相关。因此，得出结论，组氨酸血症患者的组胺代谢高于正常对照组。