Pasquier David, Lartigau Eric
Département de radiothérapie, Centre Oscar-Lambret, 59000 Lille.
Bull Cancer. 2003 Apr;90 Spec No:S152-7.
The role of oxygen as an enhancer of the biological effect of ionising radiation is crucial for radiotherapy. Most of the solid tumours have an inadequate vasculature (neo-angiogenesis) leading to hypoxic areas, favoured by anaemia. Many clinical approaches have been used to overcome this problem with oxygen breathing, radiosensitizing drugs or anaemia correction. All these parameters will be developed together with the methods available for measuring tumour oxygenation and the biological consequences of anaemia and hypoxia on tumour physiology.
氧气作为电离辐射生物效应增强剂的作用对放射治疗至关重要。大多数实体瘤血管系统不健全(新生血管生成),导致出现缺氧区域,贫血会加重这种情况。人们已采用多种临床方法来解决这一问题,如吸氧、使用放射增敏药物或纠正贫血。所有这些参数将与可用于测量肿瘤氧合以及贫血和缺氧对肿瘤生理的生物学后果的方法一起进行研究。