Kurup Ravi Kumar, Kurup Parameswara Achutha
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
Int J Neurosci. 2003 Apr;113(4):537-46. doi: 10.1080/00207450390162272.
The isoprenoid path way produces endogenous digoxin, a substance that can regulate neurotransmitter and amino acid transport. Digoxin synthesis and neurotransmitter patterns were assessed in individuals with chronic insomnia. The patterns were compared in those with right hemispheric and left hemispheric dominance. The activity of HMG GoA reductase and serum levels of digoxin, magnesium, tryptophan catabolites, and tyrosine catabolites were measured in individuals with chronic insomnia and in individuals with differing hemispheric dominance. Digoxin synthesis was increased with upregulated tryptophan catabolism (increased levels of serotonin, strychnine, and nicotine), and downregulated tyrosine catabolism (decreased levels of dopamine, noradrenaline, and morphine) in those with chronic insomnia and right hemispheric chemical dominance. Digoxin synthesis was reduced with downregulated tryptophan catabolism (decreased levels of serotonin, strychnine, and nicotine) and upregulated tyrosine catabolism (increased levels of dopamine, noradrenaline, and morphine) in those with normal sleep patterns and left hemispheric chemical dominance. Hypothalamic digoxin plays a central role in the regulation of sleep behavior. Hemispheric chemical dominance in relation to digoxin status is also crucial.
类异戊二烯途径产生内源性地高辛，一种可调节神经递质和氨基酸转运的物质。对慢性失眠患者的地高辛合成和神经递质模式进行了评估。比较了右半球优势和左半球优势患者的这些模式。测量了慢性失眠患者以及具有不同半球优势的个体中HMG GoA还原酶的活性和地高辛、镁、色氨酸分解代谢产物及酪氨酸分解代谢产物的血清水平。在慢性失眠且右半球化学优势的个体中，地高辛合成随着色氨酸分解代谢上调（血清素、士的宁和尼古丁水平升高）和酪氨酸分解代谢下调（多巴胺、去甲肾上腺素和吗啡水平降低）而增加。在睡眠模式正常且左半球化学优势的个体中，地高辛合成随着色氨酸分解代谢下调（血清素、士的宁和尼古丁水平降低）和酪氨酸分解代谢上调（多巴胺、去甲肾上腺素和吗啡水平升高）而减少。下丘脑地高辛在睡眠行为调节中起核心作用。与地高辛状态相关的半球化学优势也至关重要。
