Kurup Ravi Kumar, Kurup Parameswara Achutha
Department of Neurology, Medical College Hospital, Metabolic Disorders Research Center, Trivandrum, Kerala, India.
Int J Neurosci. 2003 Apr;113(4):565-77. doi: 10.1080/00207450390162290.
The human hypothalamus produces an endogenous membrane Na(+)-K+ ATPase inhibitor, digoxin, which regulates neuronal transmission. The digoxin status and neurotransmitter patterns were studied in creative and non-creative individuals, as well as in individuals with differing hemispheric dominance, in order to find out the role of cerebral dominance in this respect. The activity of HMG CoA reductase and serum levels of digoxin, magnesium, tryptophan catabolites, and tyrosine catabolites were measured in creative/non-creative individuals, and in individuals with differing hemispheric dominance. In creative individuals there was increased digoxin synthesis, decreased membrane Na(+)-K+ ATPase activity, increased tryptophan catabolites (serotonin, quinolinic acid, and nicotine), and decreased tyrosine catabolites (dopamine, noradrenaline, and morphine). The pattern in creative individuals correlated with right hemispheric dominance. In non-creative individuals there was decreased digoxin synthesis, increased membrane Na(+)-K+ ATPase activity, decreased tryptophan catabolites (serotonin, quinolinic acid, and nicotine), and increased tyrosine catabolites (dopamine, noradrenaline, and morphine). This pattern in non-creative individuals correlated with that obtained in left hemispheric chemical dominance. Hemispheric chemical dominance and hypothalamic digoxin could regulate the predisposition to creative tendency.
人类下丘脑会产生一种内源性膜钠钾ATP酶抑制剂地高辛，它可调节神经传递。为了探究大脑优势在这方面的作用，研究了有创造力和无创造力个体以及半球优势不同的个体的地高辛状态和神经递质模式。测量了有创造力/无创造力个体以及半球优势不同的个体中HMG CoA还原酶的活性以及地高辛、镁、色氨酸代谢产物和酪氨酸代谢产物的血清水平。有创造力的个体中，地高辛合成增加，膜钠钾ATP酶活性降低，色氨酸代谢产物（血清素、喹啉酸和烟碱）增加，酪氨酸代谢产物（多巴胺、去甲肾上腺素和吗啡）减少。有创造力个体的这种模式与右半球优势相关。无创造力的个体中，地高辛合成减少，膜钠钾ATP酶活性增加，色氨酸代谢产物（血清素、喹啉酸和烟碱）减少，酪氨酸代谢产物（多巴胺、去甲肾上腺素和吗啡）增加。无创造力个体的这种模式与左半球化学优势的情况相关。半球化学优势和下丘脑地高辛可能会调节对创造性倾向的易感性。
