Wei Qingrong, Wan Changxiu, Yao Hongwei, Li Tianquan, Xiong Yanfang
Department of Polymer Science and Engineering, Sichuan University, Chengdu 610065.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Jun;20(2):214-8.
Bovine pericardium is mainly composed of collagen which has many good properties of extracellular matrix. This in vitro study was performed to quantitatively investigate and compare the degradation behavior of the bovine pericardial, which were modified with different methods. The purpose is to find out one method that presents not only the degradation regularity of material but also minimum antigenicity, so that bovine pericardium can be used as a well degradable guide tissue regeneration material. The results of the experiments showed that the bovine pericardium treated with ethanol is more appreciated than that treated with epoxy cross-linking agent or glutaraldehyde. The mensuration of protein and special amino acid may be a useful base of constructing a mathematic model for further researches on the rate of degradation of bovine pericardium.
牛心包主要由胶原蛋白组成，其具有细胞外基质的许多良好特性。进行这项体外研究是为了定量研究和比较用不同方法改性的牛心包的降解行为。目的是找出一种不仅能呈现材料降解规律而且抗原性最小的方法，以便牛心包可用作良好的可降解引导组织再生材料。实验结果表明，用乙醇处理的牛心包比用环氧交联剂或戊二醛处理的更受青睐。蛋白质和特定氨基酸的测定可能是构建数学模型以进一步研究牛心包降解速率的有用基础。
