Chang Chao-Hsiang, Tsai Chang-Shu, Jim Yick-Fung, Wu Hsi-Chin, Lin Cheng-Chieh, Kao Albert
Department of Urology, China Medical College Hospital, Taichung, Taiwan.
Endocr Res. 2003 May;29(2):177-82. doi: 10.1081/erc-120022298.
Because of the discrepant findings on regional bone mineral density (BMD) in stage IV patients with bone metastases due to prostate cancer, we decided to evaluate BMD of lumbar spines in 30 prostate cancer patients with lumbar spine metastases. These measurements of BMD in lumbar spines were compared with 30 stage IV prostate cancer patients without lumbar spine metastases.
Before BMD measurements, the bone scan with technetium-99m labeled diphosphonate was carried out in all of the men to evaluate lumbar spine metastases. Dual energy x-ray absorptiometry was used to measure BMD in the lumbar spines.
There was no difference of age, height, weight, and body mass index between the two group patients. However, significantly higher BMD of the lumbar spines in the 30 patients of prostate cancers with lumbar spine metastases was found (p value <0.05).
Our results show that patients of prostate cancers with lumbar spine metastases demonstrated by Tc-99m MDP bone scan have increased BMD in the lumbar spines, possibly because of a predominance of osteoblastic over osteolytic metastases demonstrated by Tc-99m MDP bone scan.
由于前列腺癌导致的骨转移IV期患者区域骨密度（BMD）的研究结果存在差异，我们决定评估30例有腰椎转移的前列腺癌患者的腰椎骨密度。将这些腰椎骨密度测量结果与30例无腰椎转移的IV期前列腺癌患者进行比较。
在进行骨密度测量之前，所有男性均进行了锝-99m标记二膦酸盐骨扫描以评估腰椎转移情况。采用双能X线吸收法测量腰椎骨密度。
两组患者的年龄、身高、体重和体重指数无差异。然而，发现30例有腰椎转移的前列腺癌患者的腰椎骨密度明显更高（p值<0.05）。
我们的结果表明，经锝-99m亚甲基二膦酸盐骨扫描证实有腰椎转移的前列腺癌患者腰椎骨密度增加，可能是因为锝-99m亚甲基二膦酸盐骨扫描显示成骨转移多于溶骨转移。
