Liu Jung-Tung, Chen Yuh-Lien, Chen Wen-Chi, Chen Huey-Yi, Lin Yi-Wen, Wang Shu-Huei, Man Kee-Ming, Wan Hui-Min, Yin Wei-Hsian, Liu Po-Len, Chen Yung-Hsiang
Department of Neurosurgery, School of Medicine, Chung-Shan Medical University and Hospital, Taichung 402, Taiwan.
J Biomed Biotechnol. 2012;2012:871272. doi: 10.1155/2012/871272. Epub 2012 May 22.
Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.
色素上皮衍生因子（PEDF）最初是在视网膜色素上皮细胞中被发现的。它是一种内源性产生的蛋白质，在人体中广泛表达，如在眼睛、肝脏、心脏和脂肪组织中；它具有多种不同的生物学活性。PEDF是一种具有抗血管生成、抗肿瘤、抗氧化、抗炎、抗血栓形成、神经营养和神经保护特性的多功能蛋白质。最近，PEDF已被证明是干细胞/祖细胞相关新生血管形成的最有效抑制剂。新生血管形成是一个由来自干细胞/祖细胞的大量相互作用分子网络调节的复杂过程。PEDF还参与血管生成性眼病、肿瘤生长和心血管疾病的发病机制。治疗各种疾病的患者需要具有可耐受副作用的新型抗血管生成药物。在此，我们综述了PEDF作为一种重要的内源性抗血管生成分子的价值；我们重点关注PEDF最近被确定的作为影响干细胞/祖细胞相关新生血管形成的可能新靶分子的作用。
