Hunter Christopher A, Lieberman Linda A, Mason Nicola, Pepper Marion, Sague Sarah L, Tato Cristina, Zediak Valerie
Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Immunol Res. 2003;27(2-3):331-40. doi: 10.1385/IR:27:2-3:331.
Parasitic infections remain an important cause of disease worldwide, and it is important to understand how the immune system protects against these organisms. In addition, the study of how the immune system deals with different types of pathogens provides the opportunity to discern how innate and adaptive arms of the immune system interact to provide an integrated protective response. Costimulatory signals are an important element involved in the control of lymphocyte response, and this laboratory studies the role of the costimulatory molecules CD28 and ICOS in the events that lead to resistance to the opportunistic pathogen Toxoplasma gondii as well as the development of immune pathology associated with this infection.
寄生虫感染仍是全球疾病的一个重要病因，了解免疫系统如何抵御这些生物体非常重要。此外，研究免疫系统如何应对不同类型的病原体，为洞察免疫系统的固有免疫和适应性免疫分支如何相互作用以提供综合保护反应提供了契机。共刺激信号是控制淋巴细胞反应的一个重要因素，本实验室研究共刺激分子CD28和ICOS在导致对机会性病原体弓形虫产生抗性以及与该感染相关的免疫病理发展过程中的作用。
