Salomon L J, Bernard J P, Duyme M, Dorion A, Ville Y
Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal de Poissy-St Germain, Poissy, France.
Ultrasound Obstet Gynecol. 2003 Jul;22(1):63-6. doi: 10.1002/uog.162.
Although advances in ultrasound have facilitated the diagnosis of fetal abnormalities in the first trimester, fetal biometry at this stage of pregnancy remains underused in prenatal diagnosis. We hypothesized that charts which directly correlate measurements to crown-rump length (CRL) could be more accurate than those based on gestational age (GA) derived from CRL measurement. The aim of this study was to construct CRL-based biometric charts.
Measurements of biparietal diameter (BPD), head circumference (HC) and abdominal circumference (AC) were prospectively collected from 939 normal singleton fetuses. Charts and predictive equations were constructed from data obtained from pregnancies in which the CRL was between 45 and 84 mm and for which the outcome was normal.
Measurements of BPD, HC and AC from 880 fetuses who met the criteria were correlated with CRL and used to construct charts and predictive equations. The standard error of estimates using CRL was significantly lower than that using GA in all cases.
First-trimester growth charts and predictive equations based on CRL instead of GA are more accurate. They might have a role in quality control of first-trimester ultrasound examination and may help in the diagnosis of fetal conditions that involve early growth abnormalities.
尽管超声技术的进步有助于孕早期胎儿异常的诊断，但孕期这一阶段的胎儿生物测量在产前诊断中仍未得到充分利用。我们推测，直接将测量值与头臀长（CRL）相关联的图表可能比基于从CRL测量得出的孕周（GA）的图表更准确。本研究的目的是构建基于CRL的生物测量图表。
前瞻性收集了939例正常单胎胎儿的双顶径（BPD）、头围（HC）和腹围（AC）测量值。图表和预测方程是根据CRL在45至84毫米之间且结局正常的妊娠所获得的数据构建的。
符合标准的880例胎儿的BPD、HC和AC测量值与CRL相关，并用于构建图表和预测方程。在所有情况下，使用CRL的估计标准误差均显著低于使用GA的估计标准误差。
基于CRL而非GA的孕早期生长图表和预测方程更准确。它们可能在孕早期超声检查的质量控制中发挥作用，并可能有助于诊断涉及早期生长异常的胎儿状况。
