Ilavarasan Raju, Vasudevan Mani, Anbazhagan Sockalingam, Venkataraman Subramanian
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Old Mahabalipuram Road, Thorapakkam, Chennai, 600096, India.
J Ethnopharmacol. 2003 Aug;87(2-3):227-30. doi: 10.1016/s0378-8741(03)00147-8.
Antioxidant activity of the aqueous (AET) and methanolic extracts (MET) of the Thespesia populnea bark was investigated in rats by inducing liver injury with carbon tetrachloride:olive oil (1:1). The extracts exhibited significant antioxidant activity showing increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO). Thespesia populnea bark extracts, AET and MET, at a dose level of 500mg/kg showed significant antioxidant activity against carbon tetrachloride-induced liver injury in rats.
橄榄油（1:1）诱导大鼠肝损伤，研究了杨叶肖槿树皮水提取物（AET）和甲醇提取物（MET）的抗氧化活性。提取物表现出显著的抗氧化活性，谷胱甘肽过氧化物酶（GPX）、谷胱甘肽S-转移酶（GST）、谷胱甘肽还原酶（GRD）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）水平升高，脂质过氧化（LPO）水平降低。剂量为500mg/kg的杨叶肖槿树皮提取物AET和MET对四氯化碳诱导的大鼠肝损伤具有显著的抗氧化活性。
