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Intracellular expression of the Salmonella plasmid virulence protein, SpvB, causes apoptotic cell death in eukaryotic cells.

作者信息

Kurita Ai, Gotoh Hideo, Eguchi Masahiro, Okada Nobuhiko, Matsuura Satoshi, Matsui Hidenori, Danbara Hirofumi, Kikuchi Yuji

机构信息

Laboratory of Molecular Immunology, Center for Basic Research, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan.

出版信息

Microb Pathog. 2003 Jul;35(1):43-8. doi: 10.1016/s0882-4010(03)00066-4.

DOI:10.1016/s0882-4010(03)00066-4
PMID:12860458
Abstract

The spv genes carried on the Salmonella virulence plasmid are commonly associated with severe systemic infection in experimental animals. The SpvB virulence-associated protein has been shown to ADP-ribosylate actin, and this enzymatic activity is essential for virulence in mice. Here, we present evidence that intracellular expression of SpvB protein induces not only disruption of actin filaments but also apoptotic cell death in eukaryotic cells.

摘要

相似文献

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Intracellular expression of the Salmonella plasmid virulence protein, SpvB, causes apoptotic cell death in eukaryotic cells.
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2
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