Reyes Michele, Nisenbaum Rosane, Hoaglin David C, Unger Elizabeth R, Emmons Carol, Randall Bonnie, Stewart John A, Abbey Susan, Jones James F, Gantz Nelson, Minden Sarah, Reeves William C
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
Arch Intern Med. 2003 Jul 14;163(13):1530-6. doi: 10.1001/archinte.163.13.1530.
Chronic fatigue syndrome (CFS) is a debilitating illness with no known cause or effective therapy. Population-based epidemiologic data on CFS prevalence and incidence are critical to put CFS in a realistic context for public health officials and others responsible for allocating resources and for practicing physicians when examining and caring for patients.
We conducted a random digit-dialing survey and clinical examination to estimate the prevalence of CFS in the general population of Wichita, Kan, and a 1-year follow-up telephone interview and clinical examination to estimate the incidence of CFS. The survey included 33 997 households representing 90 316 residents. This report focuses on 7162 respondents aged 18 to 69 years. Fatigued (n = 3528) and randomly selected nonfatigued (n = 3634) respondents completed telephone questionnaires concerning fatigue, other symptoms, and medical history. The clinical examination included the Diagnostic Interview Schedule for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, laboratory testing, and a physical examination.
The overall weighted point prevalence of CFS, adjusted for nonresponse, was 235 per 100,000 persons (95% confidence interval, 142-327 per 100,000 persons). The prevalence of CFS was higher among women, 373 per 100,000 persons (95% confidence interval, 210-536 per 100,000 persons), than among men, 83 per 100,000 persons (95% confidence interval, 15-150 per 100,000 persons). Among subjects nonfatigued and fatigued for less than 6 months, the 1-year incidence of CFS was 180 per 100,000 persons (95% confidence interval, 0-466 per 100,000 persons).
Chronic fatigue syndrome constitutes a major public health problem. Longitudinal follow-up of this cohort will be used to further evaluate the natural history of this illness.
慢性疲劳综合征（CFS）是一种使人衰弱的疾病，病因不明，也没有有效的治疗方法。基于人群的CFS患病率和发病率的流行病学数据，对于公共卫生官员以及其他负责资源分配的人员，以及执业医师在检查和护理患者时将CFS置于实际背景中至关重要。
我们进行了一项随机数字拨号调查和临床检查，以估计堪萨斯州威奇托市普通人群中CFS的患病率，并进行了为期1年的随访电话访谈和临床检查，以估计CFS的发病率。该调查包括代表90316名居民的33997户家庭。本报告重点关注7162名年龄在18至69岁之间的受访者。疲劳（n = 3528）和随机选择的非疲劳（n = 3634）受访者完成了关于疲劳、其他症状和病史的电话问卷。临床检查包括《精神障碍诊断与统计手册》第四版的诊断访谈表、实验室检查和体格检查。
经无应答调整后的CFS总体加权点患病率为每10万人235例（95%置信区间为每10万人142 - 327例）。CFS的患病率在女性中较高，为每10万人373例（95%置信区间为每10万人210 - 536例），高于男性，男性为每10万人83例（95%置信区间为每10万人15 - 150例）。在非疲劳和疲劳少于6个月的受试者中，CFS的1年发病率为每10万人180例（95%置信区间为每10万人0 - 466例）。
慢性疲劳综合征构成一个重大的公共卫生问题。对该队列的纵向随访将用于进一步评估这种疾病的自然史。
