Lotric-Furlan Stanka, Petrovec Miroslav, Avsic-Zupanc Tatjana, Strle Franc
Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia.
Ann N Y Acad Sci. 2003 Jun;990:279-84. doi: 10.1111/j.1749-6632.2003.tb07377.x.
Several reports indicate the presence of infection with Anaplasma phagocytophila in Europe. The first case with confirmed human granulocytic ehrlichiosis was reported from Slovenia in 1997. By 2002, 13 patients have been discovered in a prospective study on the etiology of febrile illnesses occurring within six weeks following a tick bite, conducted at the Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. The diagnosis was established by molecular identification of ehrlichial organisms and/or by seroconversion to A. phagocytophila. None of the patients had detectable morulae on blood smear examination. Clinical characteristics and laboratory findings were similar to those reported from the United States. The severity of the illness was mild to moderately severe. All patients recovered rapidly and without sequelae. HGE should be included in the differential diagnosis of febrile illnesses occurring after a tick bite in Slovenia.
几份报告表明欧洲存在嗜吞噬细胞无形体感染。1997年，斯洛文尼亚报告了首例确诊的人类粒细胞埃立克体病病例。到2002年，在斯洛文尼亚卢布尔雅那大学医学中心传染病科对蜱叮咬后六周内发生的发热性疾病病因进行的一项前瞻性研究中，发现了13例患者。诊断通过对埃立克体生物进行分子鉴定和/或通过血清转化为嗜吞噬细胞无形体来确定。所有患者在血液涂片检查中均未发现可见的桑葚体。临床特征和实验室检查结果与美国报告的相似。疾病严重程度为轻度至中度。所有患者均迅速康复且无后遗症。在斯洛文尼亚，蜱叮咬后发生的发热性疾病的鉴别诊断应包括人类粒细胞埃立克体病。
