Bowd Christopher, Zangwill Linda M, Weinreb Robert N
Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946, USA.
Arch Ophthalmol. 2003 Jul;121(7):961-6. doi: 10.1001/archopht.121.7.961.
To compare the association between scanning laser polarimetry (SLP) retinal nerve fiber layer (RNFL) measurements and automated perimetry sensitivity using both SLP manufacturer-assumed fixed and subject-specific variable corneal polarization magnitude and corneal polarization axis values.
An SLP was modified to enable the measurement of corneal polarization magnitude and corneal polarization axis so that compensation for corneal birefringence could be corrected on a subject-specific variable basis. Seventy-three eyes from the University of California, San Diego, Diagnostic Innovations in Glaucoma Study with early glaucoma or suspected glaucoma (abnormal Swedish Interactive Threshold Algorithm [SITA] or full-threshold automated perimetry results and/or glaucomatous-appearing optic disc by consensus grading of stereoscopic optic disc photographs) (mean [SD] SITA mean deviation, -2.74 [3.71] dB; range, 1.72 to -14.72 dB) were included. Subjects were imaged with SLP using the manufacturer-assumed fixed corneal compensation values and subject-specific variable corneal compensation values and tested with SITA automated perimetry. Scanning laser polarimetry and SITA data were obtained within 3 months of each other.
The relationship between regional SLP RNFL measurements (24 parameters) and corresponding regional SITA raw thresholds were evaluated using linear regression for both (fixed corneal compensation and variable corneal compensation) SLP configurations.
No fixed corneal compensation SLP measurements were significantly associated with corresponding SITA visual field zone sensitivities after corrections for multiple comparisons. Seven variable corneal compensation RNFL parameters (superior, inferior, or mean RNFL thickness measurements) were significantly associated with their corresponding visual field zones with R2 values ranging from 0.13 (ellipse average) to 0.20 (superior average).
Variable corneal compensation to correct for subject-specific corneal polarization magnitude and corneal polarization axis improves the relationship between SLP-measured RNFL thickness and visual function measured by SITA perimetry.
使用扫描激光偏振仪（SLP）制造商假定的固定角膜偏振幅度和角膜偏振轴值以及受试者特定的可变角膜偏振幅度和角膜偏振轴值，比较扫描激光偏振仪（SLP）视网膜神经纤维层（RNFL）测量值与自动视野计敏感度之间的关联。
对SLP进行了改进，使其能够测量角膜偏振幅度和角膜偏振轴，以便可以在受试者特定的可变基础上校正角膜双折射的补偿。纳入了来自加利福尼亚大学圣地亚哥分校青光眼诊断创新研究的73只眼睛，这些眼睛患有早期青光眼或疑似青光眼（瑞典交互式阈值算法[SITA]异常或全阈值自动视野计结果和/或通过立体视盘照片的共识分级出现青光眼样视盘）（平均[标准差]SITA平均偏差，-2.74[3.71]dB；范围，1.72至-14.72dB）。使用制造商假定的固定角膜补偿值和受试者特定的可变角膜补偿值，用SLP对受试者进行成像，并用SITA自动视野计进行测试。扫描激光偏振仪和SITA数据在彼此3个月内获得。
使用线性回归评估两种（固定角膜补偿和可变角膜补偿）SLP配置下区域SLP RNFL测量值（24个参数）与相应区域SITA原始阈值之间的关系。
在进行多重比较校正后，没有固定角膜补偿的SLP测量值与相应的SITA视野区敏感度显著相关。七个可变角膜补偿RNFL参数（上方、下方或平均RNFL厚度测量值）与它们相应的视野区显著相关，R2值范围从0.13（椭圆平均值）到0.20（上方平均值）。
针对受试者特定的角膜偏振幅度和角膜偏振轴进行可变角膜补偿，可改善SLP测量的RNFL厚度与SITA视野计测量的视觉功能之间的关系。
