Kim Kyung Hoon, Choi Jaewan, Lee Chang Hwan, Cho Beom Jin, Kook Michael S
Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Korean J Ophthalmol. 2008 Mar;22(1):18-25. doi: 10.3341/kjo.2008.22.1.18.
To evaluate the structure-function relationships between retinal sensitivity measured by Humphrey visual field analyzer (HVFA) and the retinal nerve fiber layer (RNFL) thickness measured by scanning laser polarimetry (SLP) with variable corneal compensation (VCC) and enhanced corneal compensation (ECC) in glaucomatous and healthy eyes.
Fifty-three eyes with an atypical birefringence pattern (ABP) based on SLP-VCC (28 glaucomatous eyes and 25 normal healthy eyes) were enrolled in this cross-sectional study. RNFL thickness was measured by both VCC and ECC techniques, and the visual field was examined by HVFA with 24-2 full-threshold program. The relationships between RNFL measurements in superior and inferior sectors and corresponding retinal mean sensitivity were sought globally and regionally with linear regression analysis in each group. Coefficients of the determination were calculated and compared between VCC and ECC techniques.
In eyes with ABP, R2 values for the association between SLP parameters and retinal sensitivity were 0.06-0.16 with VCC, whereas they were 0.21-0.48 with ECC. The association of RNFL thickness with retinal sensitivity was significantly better with ECC than with VCC in 5 out of 8 regression models between SLP parameters and HVF parameters (P<0.05).
The strength of the structure-function association was higher with ECC than with VCC in eyes with ABP, which suggests that the ECC algorithm is a better approach for evaluating the structure-function relationship in eyes with ABP.
评估在青光眼患者和健康眼中，通过 Humphrey 视野分析仪（HVFA）测量的视网膜敏感度与通过可变角膜补偿（VCC）和增强角膜补偿（ECC）的扫描激光偏振仪（SLP）测量的视网膜神经纤维层（RNFL）厚度之间的结构 - 功能关系。
本横断面研究纳入了 53 只基于 SLP - VCC 具有非典型双折射模式（ABP）的眼睛（28 只青光眼眼和 25 只正常健康眼）。通过 VCC 和 ECC 技术测量 RNFL 厚度，并使用 24 - 2 全阈值程序通过 HVFA 检查视野。在每组中，通过线性回归分析全局和局部地寻找上半和下半象限 RNFL 测量值与相应视网膜平均敏感度之间的关系。计算并比较 VCC 和 ECC 技术之间的决定系数。
在具有 ABP 的眼中，VCC 的 SLP 参数与视网膜敏感度之间关联的 R2 值为 0.06 - 0.16，而 ECC 的 R2 值为 0.21 - 0.48。在 SLP 参数与 HVF 参数之间的 8 个回归模型中的 5 个中，ECC 下 RNFL 厚度与视网膜敏感度的关联明显优于 VCC（P < 0.05）。
在具有 ABP 的眼中，ECC 的结构 - 功能关联强度高于 VCC，这表明 ECC 算法是评估具有 ABP 的眼睛中结构 - 功能关系的更好方法。
