Koudelová J, Mourek J K
Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague.
Physiol Res. 1992;41(3):207-12.
The authors studied the effect of short-term (20 min) hypobaric hypoxia at simulated altitudes of 7000 and 9000 m on the peroxidation of lipids in the cerebral cortex, subcortical formations, medulla oblongata and cerebellum of the laboratory rat. In 5- and 21-day-old rats, increased lipoperoxidation was recorded in all the studied regions of the brain. Differences were observed in sensitivity to the degree of hypoxia. In 5-day-old rats the response to both exposures was the same, but in 21-day-old animals exposure at 7000 m stimulated peroxidation in the cerebral cortex only (at 9000 m in all the parts of the CNS examined). In 35-day-old and adult rats, changes in the malondialdehyde concentration were likewise found after exposure at 9000 m, but not in every compartment (in 35-day-old rats in the cerebral cortex and subcortical formations and in adult rats in the cerebral cortex). In young rats, 30 and 60 min after exposure to hypoxia the malondialdehyde concentration was still higher than in older animals.
作者研究了在模拟海拔7000米和9000米高度下进行短期（20分钟）低压缺氧对实验大鼠大脑皮质、皮质下结构、延髓和小脑脂质过氧化的影响。在5日龄和21日龄的大鼠中，在所有研究的脑区均记录到脂质过氧化增加。观察到对缺氧程度的敏感性存在差异。在5日龄大鼠中，对两种暴露的反应相同，但在21日龄动物中，7000米高度的暴露仅刺激大脑皮质的过氧化（9000米高度则刺激所检查的中枢神经系统所有部位的过氧化）。在35日龄大鼠和成年大鼠中，9000米高度暴露后同样发现丙二醛浓度发生变化，但并非在每个脑区都有变化（35日龄大鼠的大脑皮质和皮质下结构以及成年大鼠的大脑皮质）。在幼鼠中，缺氧暴露后30分钟和60分钟时丙二醛浓度仍高于成年动物。
