Fu Z, Wong E F, Yeung-Lai-Wah J A, Wong N L
Department of Medicine, University of British Columbia, Vancouver, Canada.
Cardiology. 1992;81(2-3):85-8. doi: 10.1159/000175781.
Previous in vitro studies showed that epinephrine stimulation can induce atrial natriuretic factor (ANF) release only form the right atrium but not from the left. In addition, sinus node has been shown to play an important role in the release of ANF. In vitro studies were done in isolated left and right rat atria to determine if pacing can induce the left atria to release ANF during epinephrine stimulation. ANF concentrations in the perfusate were measured by a radioimmunoassay method. Epinephrine increased ANF release in the right atria (from 6.3 +/- 0.8 to 10.8 +/- 0.9 pg/min/mg), but not in the unpaced left atria (4.2 +/- 0.4 and 4.2 +/- 0.3 pg/min/mg). However, when the atria were paced, ANF release rose in both the left (from 6.2 +/- 0.5 to 11.5 +/- 1.4 pg/min/mg) and right (from 8.4 +/- 1.15 to 16.6 +/- 1.8 pg/min/mg) atria with epinephrine addition. These results suggest that atrial contraction and tension play an important role in epinephrine-stimulated ANF release.
先前的体外研究表明，肾上腺素刺激仅能诱导右心房释放心房利钠因子（ANF），而不能诱导左心房释放。此外，已证明窦房结在ANF的释放中起重要作用。在离体大鼠左、右心房中进行体外研究，以确定起搏是否能在肾上腺素刺激期间诱导左心房释放ANF。通过放射免疫分析法测量灌流液中的ANF浓度。肾上腺素增加了右心房的ANF释放（从6.3±0.8增至10.8±0.9 pg/min/mg），但未增加未起搏左心房的ANF释放（4.2±0.4和4.2±0.3 pg/min/mg）。然而，当心房起搏时，添加肾上腺素后，左心房（从6.2±0.5增至11.5±1.4 pg/min/mg）和右心房（从8.4±1.15增至16.6±1.8 pg/min/mg）的ANF释放均增加。这些结果表明，心房收缩和张力在肾上腺素刺激的ANF释放中起重要作用。
