Fogo Agnes B
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kidney Int Suppl. 2003 Feb(83):S17-21. doi: 10.1046/j.1523-1755.63.s83.5.x.
African Americans with hypertension more commonly develop renal insufficiency compared to Caucasians. The African American Study of Kidney Disease (AASK) included a renal biopsy pilot study that demonstrated that the clinical diagnosis of so-called hypertensive nephrosclerosis in these African American patients indeed was accurate. This biopsy study demonstrated extensive global glomerulosclerosis, far exceeding that expected for patients' age. We further compared our clinically indicated renal biopsies to determine if any phenotypic differences were present in hypertensive nephrosclerosis in African Americans versus Caucasians. These studies point to an excess of the solidified type of global glomerulosclerosis (GS) (also called "decompensated benign nephrosclerosis") in African Americans compared to more obsolescent type GS in Caucasians. We speculate that these phenotypic differences might reflect differing mechanisms of tissue injury in hypertensive African Americans versus Caucasians, and discuss possible contributors to this injury.
与白人相比，患有高血压的非裔美国人更易出现肾功能不全。非裔美国人肾脏疾病研究（AASK）纳入了一项肾脏活检初步研究，该研究表明，这些非裔美国患者中所谓高血压性肾硬化的临床诊断确实准确。这项活检研究显示存在广泛的全球性肾小球硬化，远远超过了患者年龄预期。我们进一步比较了我们临床上所做的肾脏活检，以确定非裔美国人和白人在高血压性肾硬化方面是否存在任何表型差异。这些研究表明，与白人中更多陈旧型肾小球硬化相比，非裔美国人中凝固型全球性肾小球硬化（GS）（也称为“失代偿性良性肾硬化”）过多。我们推测，这些表型差异可能反映了高血压非裔美国人和白人在组织损伤机制上的不同，并讨论了这种损伤的可能原因。
