Hadji-Minaglou-Gonzalvez M F, Gayte-Sorbier A, Airaudo C B, Verdier M
Centre Hospitalier Régional, Faculté de Pharmacie, Marseilles, France.
Clin Ther. 1992 Nov-Dec;14(6):821-4.
The stability and absorption of carmustine were studied comparatively in glass flasks and Stedim 6 bags. Stedim 6 is a new, multilayer, polyethylene-lined film. When stored at room temperature (22 degrees C +/- 2 degrees C) in the dark, carmustine decomposed in 5% dextrose solution and more so in 0.9% sodium chloride solution. When stored at 4 degrees C +/- 0.5 degrees C, the losses were identical in the glass flasks and Stedim 6 bags (about 11% after 72 hours). As long as they are kept in the dark at 4 degrees C, carmustine admixtures can be prepared up to 48 hours before administration, in either dextrose or sodium chloride isotonic solutions, and stored in either glass flasks or Stedim 6 bags.
在玻璃瓶和Stedim 6袋中对卡莫司汀的稳定性和吸收情况进行了对比研究。Stedim 6是一种新型的多层、内衬聚乙烯的薄膜。当在室温（22摄氏度±2摄氏度）下避光储存时，卡莫司汀在5%葡萄糖溶液中会分解，在0.9%氯化钠溶液中分解得更多。当在4摄氏度±0.5摄氏度下储存时，玻璃瓶和Stedim 6袋中的损失相同（72小时后约为11%）。只要在4摄氏度下避光保存，卡莫司汀混合物可以在给药前48小时内用葡萄糖或氯化钠等渗溶液配制，并储存在玻璃瓶或Stedim 6袋中。
