骨桥蛋白：骨骼与免疫系统之间的桥梁。
Osteopontin: a bridge between bone and the immune system.
作者信息
Gravallese Ellen M
机构信息
Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 2003 Jul;112(2):147-9. doi: 10.1172/JCI19190.
Abstract
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.
摘要
骨桥蛋白在慢性炎症性疾病类风湿关节炎中假定作用的潜在分子机制尚不清楚。目前一项针对关节炎小鼠模型的研究表明，一种针对暴露的骨桥蛋白表位SLAYGLR的特异性抗体能够防止炎性细胞浸润至关节炎关节中。
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本文引用的文献
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Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.在类风湿性关节炎小鼠模型中，骨桥蛋白内隐蔽表位SLAYGLR的重要作用。
J Clin Invest. 2003 Jul;112(2):181-8. doi: 10.1172/JCI17778.
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Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease".关于“促炎细胞因子骨桥蛋白对自身免疫性脱髓鞘疾病的影响”的评论
Science. 2003 Mar 21;299(5614):1845; author reply 1845. doi: 10.1126/science.1080223.
3
Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression.骨桥蛋白缺乏会因CD44表面表达减少而导致破骨细胞功能障碍。
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Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritis.骨桥蛋白在胶原诱导性关节炎小鼠实验性关节炎模型骨侵蚀部位的表达：骨桥蛋白可能参与关节炎中的骨质破坏。
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Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.骨桥蛋白缺乏可保护小鼠抗II型胶原抗体诱导的关节炎中的关节免受破坏。
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Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.甲状旁腺激素诱导的骨吸收在骨桥蛋白缺失的情况下不会发生。
J Biol Chem. 2001 Apr 20;276(16):13065-71. doi: 10.1074/jbc.M010938200. Epub 2001 Jan 22.
8
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.骨桥蛋白信使核糖核酸及蛋白在类风湿关节炎中的表达：骨桥蛋白对关节软骨细胞及滑膜成纤维细胞释放胶原酶1的影响
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