Molloy Sean, Mathis John M, Belkoff Stephen M
The Orthopaedic Instrumentation Laboratory, Department of Orthopaedic Surgery, The Johns Hopkins University/Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224-2780, USA.
Spine (Phila Pa 1976). 2003 Jul 15;28(14):1549-54.
An ex vivo biomechanical study was conducted using osteoporotic cadaveric vertebral bodies.
To determine the relationship between the percentage of osteoporotic vertebral body volume filled with polymethylmethacrylate cement during percutaneous vertebroplasty and the percentage restoration of strength and stiffness.
A previous biomechanical study reported a weak relationship between the volume of cement injected and restoration of vertebral body strength and stiffness. Vertebral bodies vary considerably in size among regions and among spines, and the weak correlation may be attributed to the fact that the volume of vertebral bodies was not explicitly considered.
The volume of 120 vertebral bodies (T6-L5) harvested from 10 osteoporotic female cadaver spines was determined by Archimedean displacement. Compression fractures were experimentally created, and initial strength and stiffness were determined. The vertebral bodies were stabilized using bipedicular injections of 2-8 mL of cement and then recompressed, after which posttreatment strength and stiffness were measured. Linear regression was used to analyze the relationship between percentage of volume fill and percentage of restored stiffness and strength.
The correlations between percentage of fill and restored strength and stiffness were weak: r2 = 0.21 and r2 = 0.27, respectively. On average, restoration of strength and stiffness required vertebral body cement fills of 16.2% and 29.8%, respectively.
Strength and stiffness are weakly correlated with the percentage fill volume of cement injected during vertebroplasty.
使用骨质疏松症尸体椎体进行了一项体外生物力学研究。
确定经皮椎体成形术中填充聚甲基丙烯酸甲酯骨水泥的骨质疏松椎体体积百分比与强度和刚度恢复百分比之间的关系。
先前的一项生物力学研究报告称，注入的骨水泥体积与椎体强度和刚度的恢复之间存在微弱关系。椎体在不同区域和不同脊柱之间的大小差异很大，这种微弱的相关性可能归因于未明确考虑椎体体积这一事实。
通过阿基米德排水法测定从10具骨质疏松女性尸体脊柱获取的120个椎体（T6-L5）的体积。通过实验制造压缩骨折，并测定初始强度和刚度。使用双椎弓根注射2-8 mL骨水泥对椎体进行固定，然后再次压缩，之后测量治疗后的强度和刚度。使用线性回归分析体积填充百分比与恢复的刚度和强度百分比之间的关系。
填充百分比与恢复的强度和刚度之间的相关性较弱：r2分别为0.21和0.27。平均而言，恢复强度和刚度分别需要填充椎体16.2%和29.8%的骨水泥。
椎体成形术中注入的骨水泥填充体积百分比与强度和刚度之间的相关性较弱。
