Hayaran A, Wadhwa S, Bijlani V
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Dev Neurosci. 1992;14(3):181-94. doi: 10.1159/000111662.
Golgi-stained sections of the human cerebellar dentate nucleus (DN) at various gestational ages were examined to study the dendritic proliferation and maturation of the DN neurons. Bipolar cells were seen at 14-15 weeks. By 19-20 weeks, three cell types were identifiable: bipolar, hemispheric and pyriform. The cells of the dorsomedial region matured earlier than those of the ventrolateral region. In addition to the above cell types, multipolar and nuclear boundary cells were observable at 24-25 weeks. The five cell types persisted during subsequent development. At no stage of development was any neuronal organizational pattern apparent. A remarkable dendritic proliferation occurred at 27-28 weeks. Spines and filiform processes were seen at 34 weeks of intrauterine life.
研究人类小脑齿状核（DN）在不同胎龄时的树突增殖和神经元成熟情况，对不同胎龄的人类小脑齿状核进行了高尔基染色切片检查。在14 - 15周时可见双极细胞。到19 - 20周时，可识别出三种细胞类型：双极细胞、半球形细胞和梨形细胞。背内侧区域的细胞比腹外侧区域的细胞成熟得早。除上述细胞类型外，在24 - 25周时可观察到多极细胞和核边界细胞。这五种细胞类型在随后的发育过程中持续存在。在发育的任何阶段都没有明显的神经元组织模式。在27 - 28周时发生了显著的树突增殖。在宫内生活34周时可见棘突和丝状突起。
