Hayaran A, Wadhwa S, Bijlani V
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Neurosci Lett. 1993 Apr 2;152(1-2):99-102. doi: 10.1016/0304-3940(93)90493-5.
The expression of substance P (SP) was examined in dentate nucleus (DN) of human cerebellum. A spatial and temporal sequence was observed in the innervation of the DN. SP appeared at 9-10 weeks and was dense in the dorsomedial region of DN. The SP immunoreactivity continued to increase until 19-21 weeks and showed a decline in the dorsomedial region by 24 weeks. By now, however, the ventrolateral region had a denser innervation. There is thus seemingly a relation between SP innervation and gyri formation in DN. SP-positive fibers were also localized in the neuroepithelium of the IV ventricle at all the ages studied. SP-positive fibers, however, reached the cerebellar cortex only by 24 weeks.
对人小脑齿状核（DN）中P物质（SP）的表达进行了检测。在DN的神经支配中观察到了时空序列。SP在9 - 10周时出现，在DN的背内侧区域密集。SP免疫反应性持续增加直至19 - 21周，并在24周时在背内侧区域显示下降。然而，此时腹外侧区域有更密集的神经支配。因此，DN中SP神经支配与脑回形成之间似乎存在关联。在所研究的所有年龄段，SP阳性纤维也定位于第四脑室的神经上皮。然而，SP阳性纤维直到24周才到达小脑皮质。
