Pawankar Ruby
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan. Pawankar_Ruby/
Indian J Chest Dis Allied Sci. 2003 Jul-Sep;45(3):179-89.
Epidemiological evidences and clinical as well as experimental observations have suggested a link between rhinitis and asthma. This relationship between rhinitis (and sinusitis) and asthma also involve other aspects, such as viral infections and bronchial hyperreactivity. These have been further confirmed by functional and immunological evidences, challenge studies of the nose and the bronchii, and, indirectly, by observing the therapeutic effects of drugs used mainly for rhinitis on the symptoms of asthma. Therefore, the present article is a review of the most relevant experimental results, so far provided, supporting the 'One Airway One Disease' concept, the possible mechanisms involved in this link and emerging therapeutic strategies like leukotriene receptor antagonists.
流行病学证据以及临床和实验观察表明鼻炎与哮喘之间存在联系。鼻炎（和鼻窦炎）与哮喘之间的这种关系还涉及其他方面，如病毒感染和支气管高反应性。功能和免疫学证据、鼻和支气管的激发试验，以及间接观察主要用于鼻炎的药物对哮喘症状的治疗效果，进一步证实了这些联系。因此，本文回顾了目前已有的最相关实验结果，这些结果支持“一个气道，一种疾病”的概念、这种联系可能涉及的机制以及白三烯受体拮抗剂等新出现的治疗策略。
