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大鼠中III型代谢型谷氨酸受体激动剂（1S,3R,4S）-1-氨基环戊烷-1,3,4-三羧酸（ACPT-I）的抗焦虑和抗抑郁样作用

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.

作者信息

Tatarczyńska Ewa, Pałucha Agnieszka, Szewczyk Bernadeta, Chojnacka-Wójcik Ewa, Wierońska Joanna, Pilc Andrzej

机构信息

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 3 1-343 Kraków, Poland.

出版信息

Pol J Pharmacol. 2002 Nov-Dec;54(6):707-10.

PMID:12866729
Abstract

We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.

摘要

我们使用Vogel冲突饮水试验检测了(1S,3R,4S)-1-氨基环戊烷-1,3,4-三羧酸（ACPT-I）的抗焦虑样活性，同时使用Porsolt试验评估了该化合物的抗抑郁样作用。ACPT-I是一种选择性III组代谢型谷氨酸受体激动剂，海马内注射后产生剂量依赖性的抗冲突效应，脑室注射后对大鼠产生抗抑郁样效应。这些数据表明，选择性III组代谢型谷氨酸受体激动剂可能成为一类新型的抗焦虑药和/或抗抑郁药。

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Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.大鼠中III型代谢型谷氨酸受体激动剂（1S,3R,4S）-1-氨基环戊烷-1,3,4-三羧酸（ACPT-I）的抗焦虑和抗抑郁样作用
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