Smiałowska Maria, Wierońska Joanna M, Szewczyk Bernadeta, Obuchowicz Ewa
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland.
Pol J Pharmacol. 2002 Nov-Dec;54(6):723-6.
The effect of some agonists and antagonists of glutamatergic receptors (GluR) on neuropeptide Y (NPY) level in the rat hippocampus was investigated using radioimmunoassay method. The compounds were injected intraperitoneally (NMDA, ACPC and MPEP) or intrahippocampally (L-CCG, L-SOP, AIDA). It was found that NMDA induced a decrease in NPY-IR in the hippocampus. No significant changes were found after ACPC (a functional NMDA receptor antagonist) and MPEP (mGlu5 receptor antagonist). NPY-IR was significantly increased after intrahippocampal injections of group II and III mGluR agonists (L-CCG-I and L-SOP, respectively), as well as after group I mGluR antagonist AIDA. The obtained results indicate that glutamatergic metabotropic and NMDA receptors may regulate NPY expression in the hippocampus. This regulation may have some connection with modulation of anxiety by the studied compounds.
采用放射免疫分析法研究了一些谷氨酸能受体（GluR）激动剂和拮抗剂对大鼠海马中神经肽Y（NPY）水平的影响。这些化合物通过腹腔注射（NMDA、ACPC和MPEP）或海马内注射（L-CCG、L-SOP、AIDA）。结果发现，NMDA可导致海马中NPY免疫反应性降低。ACPC（一种功能性NMDA受体拮抗剂）和MPEP（mGlu5受体拮抗剂）注射后未发现显著变化。海马内注射II组和III组mGluR激动剂（分别为L-CCG-I和L-SOP）以及I组mGluR拮抗剂AIDA后，NPY免疫反应性显著增加。所得结果表明，谷氨酸能代谢型受体和NMDA受体可能调节海马中NPY的表达。这种调节可能与所研究化合物对焦虑的调节存在某种关联。
