Jemel Boutheina, Oades Robert D, Oknina Ljubov, Achenbach Christiane, Röpcke Bernd
University Clinic for Child and Adolescent Psychiatry and Psychotherapy, Essen, Germany.
Brain Topogr. 2003 Summer;15(4):249-62. doi: 10.1023/a:1023915730566.
Frontal and temporal lobe sources for electrical activity associated with auditory controlled attention (negative difference, Nd) were sought for comparison with those reported to arise from the earlier detection of stimulus-change (mismatch negativity, MMN: Jemel et al. 2002). In two sessions a month apart (T1 and T2), 14 subjects were presented with a 3-tone oddball passively, then as a discrimination task. In EEG recordings (32 sites), Nd was calculated by subtraction of the event-related potential elicited by a non-attended stimulus from that after the same frequency-deviant as target Putative generators in the 180-228 ms latency-range were modelled with brain electrical source analysis and mapped to the modified Montreal brain-atlas. Initial T1-analyses located bilateral Nd dipoles in the superior temporal gyrus (BA22) and the dorsolateral prefrontal cortex (BA8). Re-test allowed estimates of the temporal and spatial extension of activity. Peak activity occurred 14 ms later. Step-by-stepanalysis showed that the best spatial fit for the inverse-solutions extended 3-6 mm from the point sources, but for temporal lobe sources this increased 15 mm caudally. The right mid-frontal source (BA10) was rostral and ventral from that in the left superior frontal gyrus (BAB). T1 and T2 dipole strengths were well correlated. Nd measures of controlled attention localised to areas associated with sustained attention, problem-solving and working-memory. Temporal lobe sources were later and more posterior and medial than for automatic change-detection. Frontal Nd sources were more dorsal on the right and more rostral on the left than MMN dipoles reported for the right inferior frontal and left anterior cingulate. The sequence of information processing is reviewed.
研究了与听觉控制注意力相关的电活动（负向差异，Nd）的额叶和颞叶来源，以便与据报道源于早期刺激变化检测的来源（失配负波，MMN：Jemel等人，2002年）进行比较。在相隔一个月的两个时间段（T1和T2）中，14名受试者被动地接受了三音奇偶数刺激，然后进行辨别任务。在脑电图记录（32个部位）中，Nd是通过从与目标相同频率偏差刺激后引发的事件相关电位中减去未被注意刺激引发的事件相关电位来计算的。在180 - 228毫秒潜伏期范围内的假定发生器用脑电源分析进行建模，并映射到改良的蒙特利尔脑图谱上。最初的T1分析在颞上回（BA22）和背外侧前额叶皮质（BA8）中定位到双侧Nd偶极子。重新测试可以估计活动的时间和空间范围。峰值活动在14毫秒后出现。逐步分析表明，逆解的最佳空间拟合从点源向外扩展3 - 6毫米，但对于颞叶源，在尾侧增加了15毫米。右侧额中源（BA10）比左侧额上回（BAB）中的源更靠前和靠腹侧。T1和T2偶极子强度相关性良好。控制注意力的Nd测量定位于与持续注意力、问题解决和工作记忆相关的区域。与自动变化检测相比，颞叶源出现得更晚，且更靠后和内侧。与报道的右侧额下回和左侧前扣带回的MMN偶极子相比，额叶Nd源在右侧更靠背侧，在左侧更靠前。对信息处理的顺序进行了综述。
