Shareef M Ajmal, Khar Roop K, Ahuja Alka, Ahmad Farhan Jalees, Raghava Swita
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
AAPS PharmSci. 2003;5(2):E17. doi: 10.1208/ps050217.
Specific targeting of drug to the colon is recognized to have several therapeutic advantages. Drugs that are destroyed by the acidic environment of the stomach or metabolized by pancreatic enzymes are only slightly affected in the colon. Sustained colonic delivery of drugs can be useful in the treatment of nocturnal asthma, angina, and arthritis. Treatment of colonic diseases such as ulcerative colitis, Crohn's disease, and colorectal cancer is more effective with direct delivery of drugs to the colon. This article is aimed at providing insight into the design considerations and evaluation of colonic drug delivery systems. The anatomy and physiology of the lower gastrointestinal tract is discussed; then the biopharmaceutical aspects are considered in relation to drug absorption in the colon. Various approaches to colon-specific drug delivery are discussed.
药物特异性靶向结肠具有多种治疗优势。在胃的酸性环境中被破坏或被胰酶代谢的药物在结肠中受影响较小。药物的结肠持续递送可用于治疗夜间哮喘、心绞痛和关节炎。将药物直接递送至结肠对治疗结肠疾病（如溃疡性结肠炎、克罗恩病和结直肠癌）更有效。本文旨在深入探讨结肠药物递送系统的设计考量和评估。文中讨论了下消化道的解剖学和生理学；然后结合结肠中的药物吸收考虑了生物药剂学方面。还讨论了结肠特异性药物递送的各种方法。
