Ashford M, Fell J T
Department of Pharmacy, University of Manchester, U.K.
J Drug Target. 1994;2(3):241-57. doi: 10.3109/10611869408996806.
The oral delivery of drugs to the colon has applications in a variety of therapeutic areas. This review is concerned with the approaches taken to achieve a universal system for delivery. The design of such a system requires the identification and exploitation of a unique feature of the colonic environment. The use of transit times, pH and bacterial enzymes are critically assessed. In addition, the system must provide protection for the drug during transit to the colon. Upper gastro-intestinal physiology and the transit of pharmaceuticals through these regions are reviewed with reference to their relevance in achieving site specificity.
药物经口服递送至结肠在多种治疗领域都有应用。本综述关注为实现通用递送系统所采用的方法。此类系统的设计需要识别并利用结肠环境的独特特征。对转运时间、pH值和细菌酶的应用进行了严格评估。此外，该系统必须在药物向结肠转运过程中为其提供保护。参照其在实现位点特异性方面的相关性，对上消化道生理学以及药物在这些区域的转运进行了综述。
