Donaldson W L, Oriol J G, Plavin A, Antczak D F
James A. Baker Institute For Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Differentiation. 1992 Dec;52(1):69-78. doi: 10.1111/j.1432-0436.1992.tb00501.x.
Between days 36-38 of pregnancy equine trophoblastic cells of the chorionic girdle migrate and form endometrial cups. Just prior to invasion, the chorionic girdle cells express high levels of polymorphic, paternally inherited, major histocompatibility complex (MHC) class I antigens. Their descendents, the mature, invasive trophoblast cells of the endometrial cups, however, express low or undetectable levels of MHC class I antigens by day 44 of pregnancy. Experiments with MHC compatible pregnancies, the study of residual chorionic girdle cells that had failed to invade the endometrium and remained on the surface of a conceptus, and the study of chorionic girdle cells recovered on days 34-36 of pregnancy and then maintained in vitro for up to 24 days strongly suggest that the reduction of MHC class I antigen expression by mature invasive trophoblast cells of the endometrial cups is developmentally regulated. This phenomenon does not appear to be induced by a maternal antibody response or by other uterine factors acting after the chorionic girdle trophoblast cells invade the endometrium.
在妊娠第36至38天期间，绒毛带的马滋养层细胞迁移并形成子宫内膜杯。就在侵入之前，绒毛带细胞表达高水平的多态性、父系遗传的主要组织相容性复合体（MHC）I类抗原。然而，它们的后代，即子宫内膜杯成熟的、侵入性滋养层细胞，在妊娠第44天时表达低水平或无法检测到的MHC I类抗原。对MHC相容妊娠的实验、对未能侵入子宫内膜而留在孕体表面的残留绒毛带细胞的研究，以及对妊娠第34至36天回收并在体外维持长达24天的绒毛带细胞的研究，都有力地表明，子宫内膜杯成熟的侵入性滋养层细胞MHC I类抗原表达的降低是受发育调控的。这种现象似乎不是由母体抗体反应或绒毛带滋养层细胞侵入子宫内膜后起作用的其他子宫因素所诱导的。
