Donaldson W L, Oriol J G, Pelkaus C L, Antczak D F
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Placenta. 1994 Feb-Mar;15(2):123-35. doi: 10.1016/s0143-4004(05)80449-7.
Invasive equine trophoblast cells of the chorionic girdle express high levels of paternally inherited Major Histocompatibility Complex (MHC) class I antigens prior to migration into the endometrium to form the so-called endometrial cups. Three groups of experiments were performed to determine if maternally inherited MHC class I antigens are expressed on chorionic girdle cells. Results indicated that maternally and paternally inherited MHC class I antigens are co-dominantly expressed by cells of the invasive equine trophoblast, and therefore, that the expression of polymorphic equine MHC class I genes does not appear to be affected by genomic imprinting in this tissue. The demonstration that cells of the chorionic girdle were immunogenic supports the hypothesis that invasion of the maternal endometrium by chorionic girdle cells stimulates the production of anti-paternal alloantibodies normally observed in early horse pregnancy. The co-dominant expression of MHC class I antigens by invasive chorionic girdle cells has important implications for the mechanism of recognition of allogeneic fetal MHC class I antigens by the maternal immune system.
在迁移到子宫内膜形成所谓的子宫内膜杯之前，绒毛带的侵袭性马滋养层细胞表达高水平的父系遗传主要组织相容性复合体（MHC）I类抗原。进行了三组实验以确定母系遗传的MHC I类抗原是否在绒毛带细胞上表达。结果表明，母系和父系遗传的MHC I类抗原由侵袭性马滋养层细胞共显性表达，因此，多态性马MHC I类基因的表达在该组织中似乎不受基因组印记的影响。绒毛带细胞具有免疫原性的证明支持了这样的假设，即绒毛带细胞对母体子宫内膜的侵袭刺激了在马早期妊娠中通常观察到的抗父系同种异体抗体的产生。侵袭性绒毛带细胞对MHC I类抗原的共显性表达对母体免疫系统识别同种异体胎儿MHC I类抗原的机制具有重要意义。
