Bettini Roberto, Marzetta Katia, Miglioranza Alessandra, Redaelli Sandro, Maino Carlo, Maffiolini Andrea, Gorini Maurizio
Università dell'Insubria, Ospedale di Circolo, Varese.
Recenti Prog Med. 2003 Jul-Aug;94(7-8):314-20.
The aim of the present research was to verify the prognostic value of some histologic bone marrow parameters in chronic myeloproliferative disorders. Diagnostic bone marrow biopsies were revised in 38 patients with chronic myeloid leukaemia, 30 with polycythemia vera, 14 with essential thrombocythemia and 16 with idiopathic myelofibrosis-myeloid metaplasia. An unfavourable clinical evolution was associated to "granulocytic" histotype in chronic myeloid leukaemia, to "erythrocytic/granulocytic and/or megacaryocytic" histotype in polycythemia vera, to "cluster" distribution of megacaryocytes in essential thrombocythemia, to classical myelofibrosis without osteomyelosclerosis in myelofibrosis-myeloid metaplasia. Bone marrow biopsy in chronic myeloproliferative disorders provides independent diagnostic and prognostic data; we support its routine execution in this group of hematologic malignancies.
本研究的目的是验证某些组织学骨髓参数在慢性骨髓增殖性疾病中的预后价值。对38例慢性髓性白血病、30例真性红细胞增多症、14例原发性血小板增多症和16例原发性骨髓纤维化-髓样化生患者的诊断性骨髓活检进行了复查。在慢性髓性白血病中，不良临床进展与“粒细胞”组织学类型相关；在真性红细胞增多症中，与“红细胞/粒细胞和/或巨核细胞”组织学类型相关；在原发性血小板增多症中，与巨核细胞的“簇状”分布相关；在原发性骨髓纤维化-髓样化生中，与无骨硬化的经典骨髓纤维化相关。慢性骨髓增殖性疾病的骨髓活检可提供独立的诊断和预后数据；我们支持在这组血液系统恶性肿瘤中常规进行骨髓活检。
