Huynh Jean-René
Institut Jacques-Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F-75251 Paris, France.
J Soc Biol. 2003;197(1):9-15.
During early oogenesis, one cell from a cyst of 16 germ cells is selected to become the oocyte. Recent data suggest that the choice of this cell within the cyst is strongly biased as early as the cyst itself forms. However, it was further shown that, although selected, the oocyte fate needs to be maintained. The maintenance of the oocyte identity requires the activity of the Drosophila homologues of the Caenorhabditis elegans par genes. It was shown that the par genes are required for the first polarisation of the oocyte as early as in region 3 of the germarium. This reveals a striking conservation between the polarisation along the antero-posterior axis of the Caenorhabditis elegans one-cell embryo and the Drosophila oocyte.
在早期卵子发生过程中，来自16个生殖细胞组成的细胞囊中的一个细胞被选出来成为卵母细胞。最近的数据表明，早在细胞囊形成时，囊内该细胞的选择就存在强烈的偏向性。然而，进一步的研究表明，尽管已被选中，但卵母细胞的命运仍需维持。维持卵母细胞的身份需要秀丽隐杆线虫par基因的果蝇同源物发挥作用。研究表明，早在卵巢管的第3区，par基因就参与了卵母细胞的首次极化。这揭示了秀丽隐杆线虫单细胞胚胎前后轴极化与果蝇卵母细胞极化之间惊人的保守性。
