Schweisguth François
Ecole Normale Supérieure, UMR 8542 CNRS, 46, rue d'Ulm, 75005, Paris.
J Soc Biol. 2003;197(1):17-22.
During metazoan development, cell fate diversity is generated in part by asymmetric cell divisions, in which mother cells divide to produce two daughter cells with distinct developmental potentials. Adoption of different cell fates often relies on the polarised distribution and unequal segregation of cell-fate determinants. Unequal segregation of cell-fate determinants requires that the mother cell becomes polarised prior to mitosis. In response to this polarisation, cell-fate determinants localise asymmetrically and the mitotic spindle lines up with the pole to which cell-fate determinants accumulate, thereby leading to their unequal partitioning upon cytokinesis. I review here the regulatory mechanisms that establish cell asymmetry and orient this asymmetry relative to the body axis in the sensory organ lineages of Drosophila.
在后生动物发育过程中，细胞命运的多样性部分是由不对称细胞分裂产生的，即母细胞分裂产生两个具有不同发育潜能的子细胞。采用不同的细胞命运通常依赖于细胞命运决定因子的极化分布和不均等分离。细胞命运决定因子的不均等分离要求母细胞在有丝分裂之前极化。作为对这种极化的反应，细胞命运决定因子不对称定位，有丝分裂纺锤体与细胞命运决定因子积累的极对齐，从而导致它们在胞质分裂时不均等分配。我在此综述了在果蝇感觉器官谱系中建立细胞不对称并使其相对于体轴定向的调控机制。
