Knoblich J A
Research Institute of Molecular Pathology (IMP), Dr Bohr Gasse 7, A-1030 Vienna, Austria.
Nat Rev Mol Cell Biol. 2001 Jan;2(1):11-20. doi: 10.1038/35048085.
Although most cells produce two equal daughters during mitosis, some can divide asymmetrically by segregating protein determinants into one of their two daughter cells. Interesting parallels exist between such asymmetric divisions and the polarity established in epithelial cells, and heterotrimeric G proteins might connect these aspects of cell polarity. The discovery of asymmetrically segregating proteins in vertebrates indicates that the results obtained in invertebrate model organisms might also apply to mammalian stem cells.
尽管大多数细胞在有丝分裂过程中产生两个相等的子细胞，但有些细胞可以通过将蛋白质决定因子分离到两个子细胞之一中进行不对称分裂。这种不对称分裂与上皮细胞中建立的极性之间存在有趣的相似之处，并且异源三聚体G蛋白可能将细胞极性的这些方面联系起来。在脊椎动物中发现不对称分离的蛋白质表明，在无脊椎动物模型生物中获得的结果也可能适用于哺乳动物干细胞。
