Schou Søren, Holmstrup Palle, Skovgaard Lene Theil, Stoltze Kaj, Hjørting-Hansen Erik, Gundersen Hans Jørgen G
Departments of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen and University Hospital (Rigshospitalet), Denmark.
Clin Oral Implants Res. 2003 Aug;14(4):404-11. doi: 10.1034/j.1600-0501.2003.120910.x.
The purpose of the present study was to evaluate the effect of autogenous bone graft particles and expanded polytetrafluoroethylene (ePTFE) membrane in the treatment of peri-implantitis with stereologic and histologic methods. Clinical and radiographic findings are reported elsewhere. Experimental peri-implantitis with a bone loss of 4-6 mm was established during 14-22 months around 64 implants with a titanium plasma-sprayed (TPS) surface in eight cynomolgus monkeys (Macaca fascicularis). The defects were treated with autogenous bone+membrane (B+M), autogenous bone (B), membrane (M), or a conventional flap procedure (control) (C). The animals were killed 6 months after surgery. Healthy peri-implant tissue was established irrespective of the applied treatment procedure. However, the amount of bone (autogenous bone graft particles and regenerated bone) and re-osseointegration were significantly higher in defects treated with B+M as compared with the three other treatment modalities. A mean bone-to-implant contact of 45% was estimated within defects treated with B+M. The corresponding values for the B, M, and C groups were 22, 21, and 14%. The present study therefore demonstrates that autogenous bone graft particles covered by an ePTFE membrane is a useful surgical treatment procedure of experimental peri-implantitis around implants with a TPS surface in cynomolgus monkeys. Obviously, there is a background for long-term evaluation in humans.
本研究的目的是采用体视学和组织学方法评估自体骨移植颗粒和膨体聚四氟乙烯（ePTFE）膜在治疗种植体周围炎中的作用。临床和影像学结果已在其他地方报道。在8只食蟹猴（猕猴）中，围绕64颗具有钛等离子喷涂（TPS）表面的种植体，在14 - 22个月内造成骨丢失4 - 6mm的实验性种植体周围炎。这些缺损分别采用自体骨+膜（B+M）、自体骨（B）、膜（M）或传统翻瓣手术（对照）（C）进行治疗。术后6个月处死动物。无论采用何种治疗方法，均建立了健康的种植体周围组织。然而，与其他三种治疗方式相比，B+M治疗的缺损部位骨量（自体骨移植颗粒和再生骨）和再骨结合明显更高。在B+M治疗的缺损部位，估计平均骨与种植体接触率为45%。B、M和C组的相应值分别为22%、21%和14%。因此，本研究表明，在食蟹猴中，用ePTFE膜覆盖的自体骨移植颗粒是治疗TPS表面种植体周围实验性种植体周围炎的一种有效手术治疗方法。显然，有必要在人体中进行长期评估。
