Patil Chayya, Agrawal Amit, Abullais Shahabe Saquib, Arora Suraj, Khateeb Shafait Ullah, Fadul A Elagib Mohamed
Department of Periodontics, M.G.V's K.B.H Dental College and Hospital, Nasik 422022, India.
Department of Periodontics and Community Dental Sciences, King Khalid University, Abha 61421, Saudi Arabia.
Antibiotics (Basel). 2022 Apr 28;11(5):593. doi: 10.3390/antibiotics11050593.
To evaluate the most effective chemotherapeutic agent for decontamination of infected dental implants.
A systematic electronic literature search in MEDLINE (PubMed) and Google scholar between January 2010 to December 2021 was carried out by using the PRISMA guidelines. A total of five studies related to chemical decontamination of the dental implant were evaluated. The search strategy was based on the PICOS framework. Randomized controlled trials (RCT's) and cohort studies evaluating the effectiveness of different chemotherapeutic agents for the decontamination of dental implants were included in the study. The outcome variable examined was the most effective chemotherapeutic agent(s) for dental implant surface decontamination after comparing the chemotherapeutic agents used in the qualifying studies.
Out of the basic database of 1564 records, 1380 articles were excluded due to irrelevance, unavailability, and repetition. Furthermore, 134 articles were excluded from 184 studies for various reasons. After further filtration, 13 studies were shortlisted. Two investigators (SSA and SA) appraised the quality of the selected studies using the risk of bias assessment tool. After excluding eight studies, five articles were finally included in the present systematic review.
The data reported for the efficacy of chemotherapeutic agents in cleaning contaminated titanium surfaces are scarce, thus it is not possible to draw a definite conclusion. However, chlorhexidine (CHX) (0.2%, 0.12%), citric acid (40%) and sodium hypochlorite (1%) are the most commonly used chemotherapeutic agents; amongst them, citric acid showed the highest potential for biofilm removal from the contaminated implant surface. All three agents [CHX (0.2%, 0.12%), citric acid (40%), and sodium hypochlorite (1%)] can be recommended as therapeutic agents along with their curbs.
评估用于感染牙种植体去污的最有效化疗药物。
按照PRISMA指南，于2010年1月至2021年12月期间在MEDLINE（PubMed）和谷歌学术上进行了系统的电子文献检索。共评估了五项与牙种植体化学去污相关的研究。检索策略基于PICOS框架。本研究纳入了评估不同化疗药物对牙种植体去污效果的随机对照试验（RCT）和队列研究。在比较合格研究中使用的化疗药物后，所检查的结果变量是用于牙种植体表面去污的最有效化疗药物。
在1564条记录的基础数据库中，有1380篇文章因不相关、不可获取和重复而被排除。此外，在184项研究中有134篇文章因各种原因被排除。经过进一步筛选，13项研究入围。两名研究者（SSA和SA）使用偏倚风险评估工具对所选研究的质量进行了评估。在排除八项研究后，最终有五篇文章纳入本系统评价。
关于化疗药物清洁受污染钛表面疗效的数据稀少，因此无法得出明确结论。然而，洗必泰（CHX）（0.2%，0.12%）、柠檬酸（40%）和次氯酸钠（1%）是最常用的化疗药物；其中，柠檬酸从受污染种植体表面去除生物膜的潜力最高。所有三种药物[CHX（0.2%，0.12%）、柠檬酸（40%）和次氯酸钠（1%）]均可作为治疗药物及其使用限制一同被推荐。
