Diaz Norys Josefina, Patricio Francy Silva, Fagundes-Neto Ulysses
Departamento de Pediatria, Universidade Federal de São Paulo, Brasil.
Arq Gastroenterol. 2002 Oct-Dec;39(4):260-7. doi: 10.1590/s0004-28032002000400010. Epub 2003 Jul 16.
Recent studies indicate the importance of eosinophilis infiltrated in the rectal mucous which jointly with the clinical features can serve to establish the diagnostic of allergic colitis.
To describe prospectively, the clinical features and morphological abnormalities of the rectal mucosa in patients with rectal bleeding and clinical diagnosis of cow's milk allergy.
Clinical features of 20 infants under 6 months of age were described. Morphological findings in rectal mucosa were compared with control group, with suspicion of congenital megacolon.
The mean age of the patients was 97 +/- 47 days, rectal bleeding started before 120 days in 85% of them; 40% were breastfed, 60% cow's milk formula or both. The most striking morphological feature, in 18 patients, was eosinophilic infiltration in the rectal mucosa. There was a significant statistical difference when these values were compared with control group.
The increased number of eosinophils in the rectal mucosa represent the most important characteristic of allergic colitis, in patients under 6 months, with rectal bleeding, when breastfed, cow's milk formula or both.
近期研究表明，浸润于直肠黏膜的嗜酸性粒细胞具有重要意义，其与临床特征共同有助于过敏性结肠炎的诊断。
前瞻性描述直肠出血且临床诊断为牛奶过敏的患者直肠黏膜的临床特征及形态学异常。
描述了20例6个月以下婴儿的临床特征。将直肠黏膜的形态学发现与疑似先天性巨结肠的对照组进行比较。
患者的平均年龄为97±47天，85%的患者在120天前开始出现直肠出血；40%为母乳喂养，60%为牛奶配方奶喂养或两者兼而有之。18例患者最显著的形态学特征是直肠黏膜嗜酸性粒细胞浸润。与对照组比较时，这些值存在显著统计学差异。
直肠黏膜嗜酸性粒细胞数量增加是6个月以下直肠出血、母乳喂养、牛奶配方奶喂养或两者兼而有之的患者过敏性结肠炎的最重要特征。
