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[对牛奶蛋白过敏引起的嗜酸性粒细胞性结肠炎]

[Eosinophilic colitis caused by allergy to cow's milk protein].

作者信息

Rossel M, Ceresa S, Las Heras J, Araya M

机构信息

Departamento de Pediatría, Facultad de Medicina, Universidad de Chile.

出版信息

Rev Med Chil. 2000 Feb;128(2):167-75.

Abstract

Eosinophilic colitis is one of the clinical manifestations of allergy to cow's milk during the first year of life. We report a series of 9 infants who, under 9 months of age and while clinically well, presented rectal bleeding of variable magnitude, with or without diarrhea, shortly after a cow's milk-based formula was initiated (n = 6); yet, 3 cases received only breast feeding. Bleeding disappeared in all patients after milk withdrawal from the diet. Challenges were planned after 12 months of treatment; three patients have not yet reached this moment, 3 had a negative challenge at 12, 18 and 28 months of age and are on a complete diet, and 3 are still on cow's milk free diet because ingestion of milk at 12, 18 and 25 months still induced rectal bleeding. This series of patients gathered in 3 years, follows the trend reported in many countries that there is a relative increase of patients diagnosed with allergy conditions early in life.

摘要

嗜酸性粒细胞性结肠炎是1岁以内对牛奶过敏的临床表现之一。我们报告了一组9例婴儿,年龄在9个月以下,临床状况良好,在开始食用以牛奶为基础的配方奶后不久(n = 6),出现了不同程度的直肠出血,伴有或不伴有腹泻;然而,3例仅接受母乳喂养。所有患者在饮食中停止摄入牛奶后出血消失。计划在治疗12个月后进行激发试验;3例患者尚未达到这个阶段,3例在12、18和28个月时激发试验为阴性,目前饮食正常,还有3例仍采用无牛奶饮食,因为在12、18和25个月时摄入牛奶仍会诱发直肠出血。这组在3年内收集的患者,遵循了许多国家报道的趋势,即早年被诊断为过敏疾病的患者相对增加。

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