五种医学上重要的念珠菌属菌种的凝集素分型

Lectin typing of five medically important Candida species.

作者信息

Muñoz A, Alonso B, Alvarez O, Llovo J

机构信息

Department of Microbiology and Parasitology, Faculty of Biology, University of Santiago de Compostela, Spain.

出版信息

Mycoses. 2003 Apr;46(3-4):85-9. doi: 10.1046/j.1439-0507.2003.00815.x.

DOI:10.1046/j.1439-0507.2003.00815.x

PMID:12870195

Abstract

This study reports the patterns of agglutination of 93 clinical Candida isolates by 14 commercial lectins. The isolates were of the species Candida albicans (55), C. tropicalis (12), C. guilliermondii (10). C. glabrata (eight) and C. parapsilosis (eight). Hundred percent of isolates were agglutinated, at least, by a panel of three lectins: Canavalia ensiformis (ConA), Lens culinaris (LCA) and Pisum sativum (PSA), all of them with alpha-D-mannose specificity. In addition, another panel of three lectins could distinguish between C. glabrata, C. tropicalis and C. albicans. Lectin typing may be of potential value for taxonomic and epidemiological studies of yeasts in clinical laboratories.

摘要

本研究报告了14种商业凝集素对93株临床念珠菌分离株的凝集模式。这些分离株包括白色念珠菌（55株）、热带念珠菌（12株）、季也蒙念珠菌（10株）、光滑念珠菌（8株）和近平滑念珠菌（8株）。所有分离株至少被一组三种凝集素凝集：刀豆球蛋白A（ConA）、菜豆凝集素（LCA）和豌豆凝集素（PSA），它们都具有α-D-甘露糖特异性。此外，另一组三种凝集素可以区分光滑念珠菌、热带念珠菌和白色念珠菌。凝集素分型可能对临床实验室中酵母的分类学和流行病学研究具有潜在价值。