de-Paris Fernanda, Sant'Anna Marcia K, Vianna Monica R M, Barichello Tatiana, Busnello Joao V, Kapczinski Flavio, Quevedo Joao, Izquierdo Ivan
Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
J Psychopharmacol. 2003 Jun;17(2):184-8. doi: 10.1177/0269881103017002006.
The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.
研究了加巴喷丁400毫克和800毫克对模拟公开演讲（SPS）诱发的焦虑的影响。32名正常男性志愿者（年龄在17至30岁之间）在SPS过程中通过自我量表[视觉模拟情绪量表（VAMS）和情绪状态剖面图（POMS）]评估他们的焦虑和情绪。同时测量了生理指标（心率和血压）。800毫克加巴喷丁治疗减轻了VAMS项“平静-兴奋”得分降低的受试者的焦虑。此外，接受400毫克和800毫克加巴喷丁治疗的志愿者在POMS中的敌意得分降低。我们的结果与其他研究一致，表明加巴喷丁具有抗焦虑潜力。
