Waikar Chandrakant, Singh Jaideep, Gupta Deepesh, Agrawal Aditya
Department of Anaesthesiology, GMC Bhopal, Madhya Pradesh, India.
Anesth Essays Res. 2017 Jul-Sep;11(3):558-560. doi: 10.4103/aer.AER_34_17.
The aim of the present study was to evaluate and compare the effect of clonidine 200 μg and gabapentin 900 mg and pregabalin 150 mg in attenuation of the hemodynamic response to laryngoscopy and intubation in normotensive patients undergoing elective surgery.
Ninety adult patients between 18 and 60 years are enrolled in the study. Patients with American Society of Anesthesiologists Grade-I and Grade-II are included which are posted for elective surgery under general anesthesia. Patients were divided into three groups: A, B, and C and received oral drugs 90 min before induction of general anesthesia, pregabalin 150, gabapentin 900mg, and clonidine 200 μg, respectively. Hemodynamic parameters such as heart rate and blood pressure were noted just before the (basal) administration of the drug, and in operation room, readings were recorded before intubation (T0) and after intubation at 1, 3, 5, and 10 min. Sedation and anxiety score were noted after 1 h of oral administration of the drug.
Mean arterial pressure was well attenuated by pregabalin than others, and mean heart rate following laryngoscopy and intubation was attenuated by clonidine group significantly.
We conclude that oral pregabalin and gabapentin attenuate blood pressure response fairly well and heart rate significantly attenuated by clonidine. All three drugs are very effective for relieving anxiety and improving sedation.
本研究旨在评估并比较200μg可乐定、900mg加巴喷丁和150mg普瑞巴林对接受择期手术的血压正常患者喉镜检查和插管时血流动力学反应的减弱效果。
90名年龄在18至60岁之间的成年患者纳入本研究。纳入美国麻醉医师协会分级为Ⅰ级和Ⅱ级、拟在全身麻醉下接受择期手术的患者。患者分为三组：A组、B组和C组，分别在全身麻醉诱导前90分钟口服药物，即150mg普瑞巴林、900mg加巴喷丁和200μg可乐定。在给药前（基础值）、手术室插管前（T0）以及插管后1、3、5和10分钟记录心率和血压等血流动力学参数。口服药物1小时后记录镇静和焦虑评分。
普瑞巴林对平均动脉压的减弱效果优于其他药物，可乐定组对喉镜检查和插管后的平均心率减弱效果显著。
我们得出结论，口服普瑞巴林和加巴喷丁对血压反应的减弱效果相当好，可乐定对心率的减弱效果显著。这三种药物在缓解焦虑和改善镇静方面均非常有效。
